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apalutamide will lessen the level or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicines which are CYP2C19 substrates can result in reduce publicity to these medications.tazemetostat will decrease the level or effect of diazepam by